Jan 282019

Toxicology and Drugs is a essential part of MRCP exam carrying 16 marks in the exam. Most student usual attain low marks in this section. Toxicology and Drugs is the study of  the nature, effects, and detection of poisons. Medicos Library has provided high standard Toxicology and Drugs on examination revision materials for medical exams.

Clinical pharmacology, therapeutics and clinical toxicology

  • Pharmacology
    - Mechanisms by which drugs produce their pharmacological effects
    - Basic principles of agonism and antagonism
    - Clinical implication of drugs that act at different receptor sites
    - Links between the pharmacological effects of drugs at the molecular level, the cellular level, and the tissue / organ level, and how these are affected by disease processes and other drugs
    - Principles by which both therapeutic and adverse effects occur
  • Clinical pharmacokinetics
    - Processes of drug absorption and distribution
    - Bio-transformation and excretion
    - Concepts of drug half-life and clearance
    - First order and zero order kinetics
  • Monitoring drug therapy
    - Direct measurement of therapeutic response
    - Measurement of plasma drug concentrations
    - Scientific basis for the measurement of drug concentration and its link to the principles of pharmacokinetics
  • Adverse drug reactions
    - Epidemiology of adverse drug reactions: recognition and avoidance
    - Important adverse effects of commonly used drugs
    - Importance of adverse drug reaction reporting schemes
  • Drug interactions
    - Adverse drug interactions and mechanisms by which interaction may occur
    - Common drug interactions and their clinical consequences
  • Pharmacogenetics
    - Principles of pharmacogenetics and its importance in determining variations in response to drugs in man, both in term of efficacy and toxicity
    - Clinical consequences of the common pharmacogenetic variations relevant to clinical practice
  • Therapeutics for specific patient groups
    - Principles of therapeutics as they apply in the following circumstances:
    The elderly
     Pregnancy and breast feeding
    — Patients with renal disease
     Patients with hepatic disease
    —– Effects of these altered physiology on the pharmacokinetics and pharmacodynamics of drugs
     Principle underlying drug choice, in pregnancy and breast feeding
     Teratogenic effects of drugs that may be used in pregnancy – Drugs that may produce toxicity in the case of renal and hepatic disease
  • Clinical toxicology
    - Principle of management of patients poisoned by drugs or other toxic substances
    - Assessment, recognition of common symptom patterns
    - Principles of removal of toxic substances
    - Antidotes where these approaches may be appropriate
  • Criteria for selecting drugs in a therapeutic class
    - Criteria used to select a drug from among drugs in a popular therapeutic class including:
    Differences in pharmacokinetics and pharmacodynamics
     The approved indications of the drug 
     Possible adverse effects or drug inteactions 
     Cost effectiveness 
    —– Used to describing studies that may be used to underpin drug selection
  • Drug formulations and routes of administration
    - Various formulations of medicines available
    - Routes by which medicines may be administered
    - Advantages and disadvantages of various routes and preparation
    - Most appropriate formulation selection and drug administration in common clinical scenarios

MRCP(UK) develops and delivers postgraduate medical examinations around the world on behalf of the three Royal Colleges of Physicians of the UK.

Part 1 at a glance

  • one-day examination
  • two three-hour papers
  • 200 mutiple-choice (best of five) questions
  • no images
  • sat in an examination hall.

Exam pass marks

MRCP(UK) examinations

Examination Pass mark
Part 1 540
Part 2 Written 454
PACES 130 (see individual skills breakdown below)

The composition of the papers is as follows:

Specialty Number of questions*
Cardiology 15
Clinical haematology and oncology 15
Clinical Pharmacology, Therapeutics and Toxicology 16
Emergency and Critical care
Clinical sciences** 25
Dermatology 8
Endocrinology 15
Geriatric medicine 4
Gastroenterology 15
Infectious diseases and GUM 15
Neurology 15
Nephrology 15
Ophthalmology 4
Psychiatry 8
Respiratory medicine 15
Rheumatology 15

* This should be taken as an indication of the likely number of questions – the actual number may vary slightly.

** Clinical sciences comprise:

Cell, molecular and membrane biology 2
Clinical anatomy 3
Clinical biochemistry and metabolism 4
Clinical physiology 4
Genetics 3
Immunology 4
Statistics, epidemiology and evidence-based medicine 5

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